Immunomodulation of the tumor microenvironment by neutralization of Semaphorin 4D
نویسندگان
چکیده
Semaphorin 4D is highly expressed at the invasive tumor margin and acts as a guidance molecule, restricting movement of tumoricidal immune cells into the tumor microenvironment. We recently showed that antibody neutralization of SEMA4D augmented activated monocyte and anticancer T-cell tumor penetration and that anti-SEMA4D antibody potentiated other immunomodulatory therapies in murine tumor models.
منابع مشابه
Semaphorin 4D produced by human head and neck squamous cell carcinoma induces myeloid derived suppressor cells expansion from peripheral blood monocytes
Background Immune suppression is one of the hallmarks by which head and neck squamous cell carcinoma (HNSCC) develops a tumor permissible environment[1]. Semaphorin 4D (Sema4D), known for its various developmental, physiological and pathological effects, was recently shown to play a role in regulating the immune system[2]. Sema4D is expressed in many epithelial tumors including HNSCC[3]; yet, t...
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Semaphorin 4D (SEMA4D, CD100) and its receptor plexin-B1 (PLXNB1) are broadly expressed in murine and human tumors, and their expression has been shown to correlate with invasive disease in several human tumors. SEMA4D normally functions to regulate the motility and differentiation of multiple cell types, including those of the immune, vascular, and nervous systems. In the setting of cancer, SE...
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